An overview of system requirements is provided in System requirements on Linux. The sections that follow discuss any relevant details.
Hardware Requirements
Software Requirements
155MB of disk space for Enterprise Edition (32-bit) plus documentation
Any distribution with glibc 2.3.3 or later.
175MB of disk space for Enterprise Edition (64-bit) plus documentation
GTK+ 2 (version 2.4 or higher) to run the GTK+ GUI. Open Motif 2.2.x and Imlib to run the deprecated Motif GUI
Any modern machine is likely to have sufficient RAM to run LispWorks as distributed.
Firefox or Opera web browser for viewing on-line documentation
LispWorks Release Notes and Installation Guide - 23 Dec 2011