Utilities which attempt to "clean up" your Mac by removing unused parts of an image can damage LispWorks itself and also LispWorks applications.
If you use such a utility on your LispWorks development machines, configure it to ignore LispWorks.
If you distribute a LispWorks application, document that it may be damaged by utilities which attempt to clean up a Mac by removing unused parts of an image. To prevent this, such utilities should be configured to ignore the LispWorks application.
As an example, CleanMyMac has an Ignore List which includes LispWorks by default, but will not include your LispWorks runtime application until you add it.
LispWorks Delivery User Guide - 10 Aug 2017